• Dr. Ioana Ilie is currently a Postdoctoral Researcher in the Caflisch group.

    Mission Statement:

    Ioana-Măriuca Ilie did her Ph.D. in Computational Biophysics at the University of Twente in the Netherlands under the supervision of Prof. Wim Briels. Her research focused on developing coarse-grained models to simulate protein aggregation on realistic timescales. She joined the Caflisch group in May 2017 as a postdoctoral researcher to explore the structural rearrangements during amyloid-β fibril elongation, the molecular process associated with the toxic species found in the brains of patients with Alzheimer’s disease.

    Her research interests focus on protein aggregation mechanisms in neurodegenerative disorders, on protein folding, and on soft matter in general. In her free time she loves to travel, play volleyball and dance.

    Google Scholar

    Below is a list of publications associated with the work in the Briels group.

    • Ilie I.M., Nayar D, den Otter W.K., van der Vegt N.F.A. and Briels W.J. Intrinsic Conformational Preferences and Interactions in α-synuclein Fibrils: Insights from Molecular Dynamics Simulations J.C.T.C. 6, 3298. DOI (2018)
    • Ilie I.M., den Otter W.K. and Briels W.J. The attachment of α-synuclein to a fiber: A coarse-grain approach. J. Chem. Phys. 146, 115102. DOI (2017)
    • Ilie I.M., den Otter W.K. and Briels W.J. A coarse grained protein model with internal degrees of freedom. Application to α-synuclein aggregation. J. Chem. Phys. 142, 085103, DOI (2016)
    • Ilie I.M. Chameleon behaviour of α-synuclein. Brownian Dynamics simulations of protein aggregation. Doctoral thesis, DOI (2015)
    • Ilie I.M., Briels W.J. and den Otter W.K. An elementary singularity-free Rotational Brownian Dynamics algorithm for anisotropic particles. J. Chem. Phys. 142, 114103, DOI (2015)
    • Ilie I.M., den Otter W.K. and Briels W.J. Rotational Brownian Dynamics simulations of clathrin cage formation. J. Chem. Phys. 141, 065101, DOI (2014)

    Dr. Ioana Ilie has been a member of the Caflisch group from 05/2017 - current.

    Email address:

    i [dot] ilie [at] bioc [dot] uzh [dot] ch