Open Positions

We are always interested in welcoming new members to our group (please see bottom of page). At the moment, we are also looking for new members to join us to contribute specifically to two projects.

Cell Biology for Drug Discovery: Internship or Research Associate Position

The project focuses on epitranscriptomic modulation of gene expression as potential anticancer therapy. The Intern/Research Associate will provide technical, scientific, and organizational support in operation of the laboratory research activities. The candidate will assist and support cell-based studies for drug discovery and development. Additionally, the Intern/Research Associate works closely with their immediate supervisor and other laboratory personnel, assists in the collection, entry, and analysis of data, culturing and storing cells, and conducting laboratory procedure according to established protocols. The molecular biology and biochemistry techniques used in the laboratory include:

  • PCR, plasmid cloning
  • TR-FRET assay
  • bacterial and mammalian cell culture
  • RNA interference (siRNA and plasmid transfection of mammalian cells)
  • target engagement assays (i.e., CETSA, InCell Pulse)
  • fluorescence microscopy
  • luciferase assay
  • Western Blotting
  • ELISA assay
  • qRT-PCR
  • mRNA isolation using magnetic beads
  • RNA dot blot
  • RNAseq

Preferred Qualifications:

  • Bachelor’s or Master’s Degree in related scientific discipline
  • Experience working in a research laboratory in the areas of Cell Biology, Molecular Biology, Biochemistry or related fields
  • Analytical skills to follow protocols and troubleshoot problems
  • Good communication and interpersonal skills
  • Experience in performing some of the aforementioned laboratory techniques and good record keeping
  • Knowledge of chemicals and requirements for safe handling procedures
  • Strong enthusiasm to contribute pro-actively to a project in a multidisciplinary research group

Job Details:
Duration: 12 months with possibility of prolongation or employment as a PhD candidate.
Salary: according to regulations of the University of Zurich.
Application: please send your CV, transcripts of your exams, master’s thesis, and a recommendation letter to Prof. Amedeo Caflisch (caflisch [at] bioc [dot] uzh [dot] ch). All documents should be attached in pdf format and preferably a single pdf file with all documents.

Master theses in experimental biochemistry/biophysics

We currently have openings for master thesis work in the experimental part of the lab. You can find the details by following this link:
UZH official announcement

General information

Applications to join our group are ALWAYS welcome from outstanding and enthusiastic Ph.D. and postdoctoral candidates. We offer a stimulating research environment at a highly ranked department within a university of excellent international standing. The quality of life in Zurich and in Switzerland in general is outstanding and well-documented by popular rankings.

There are frequently open positions in the laboratory and the best is to inquire. All our research projects are aimed at studying biological macromolecular systems. Current focus areas are situated in pathogenic protein aggregation and cancer therapeutics with a focus on epigenetics. Various projects have a strong component of methodology development while others require the application of existing approaches. Possible subjects include using molecular dynamics simulations to understand peptide aggregation and peptide-protein binding, the characterization of small molecule binding to macromolecules by simulation, theory, and experiment, the development of new ligands for therapeutically relevant targets by docking or de novo ligand design, and the development of new methods and models for classical biomolecular simulations. Applicants should preferably hold a Masters or Ph.D. degree in physics, biophysics, chemistry, or biochemistry. We also perform experiments, specifically protein crystallography and a number of in vitro binding and functional assays such as surface plasmon resonance. For computational applicants in particular, programming skills and a familiarity with the Linux operating system are highly advantageous.  Individuals interested in applying for a postdoc position should submit a letter of application, resume, and the names of three professional references to Prof. A. Caflisch: caflisch[at]

Please refer to the contact page for how to reach us or contact us by phone or postal mail. Prospective doctoral students are encouraged to also familiarize themselves with the various Ph.D. programs offered by the University of Zurich or jointly with the ETH. Some pointers are provided on a separate page.