Biblio

Found 13 results
Filters: Author is Bedi, R. K.  [Clear All Filters]
2024
Corbeski I., Vargas-Rosales P.A, Bedi R.K, Deng J., Coelho D., Braud E., Iannazzo L., Li Y., Huang D., Ethève-Quelquejeu M. et al..  2024.  The catalytic mechanism of the RNA methyltransferase METTL3. eLife. 12:RP92537.
Zálešák F., Nai F., Herok M., Bochenkova E., Bedi R.K, Li Y., Errani F., Caflisch A..  2024.  Structure-based design of a potent and selective YTHDC1 ligand. Journal of Medicinal Chemistry. 67(11):9516-9535.
Cheng-Sánchez I., Gosselé K., Palaferri L., Laul E., Riccabella G., Bedi R.K, Li Y., Müller A., Corbeski I., Caflisch A. et al..  2024.  Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity. Journal of the American Chemical Society Au. 4(9):3466-3474.
2023
Bedi R.K, Huang D., Li Y., Caflisch A..  2023.  Structure-Based Design of inhibitors of the m6A‑RNA writer enzyme METTL3. ACS Bio & Med Chem Au. 3(4):359–370.
2022
Li Y., Bedi R.K, Nai F., von Roten V., Dolbois A., Zálešák F., Nachawati R., Huang D., Caflisch A..  2022.  Structure-based design of ligands of the m6A-RNA reader YTHDC1. European Journal of Medicinal Chemistry Reports. 5:100057.
2021
Dolbois A., Bedi R.K, Bochenkova E., Müller A., Moroz-Omori E.V, Huang D., Caflisch A..  2021.  1,4,9-Triazaspiro[5.5]undecan-2-one derivatives as potent and selective METTL3 inhibitors. Journal of Medicinal Chemistry. 64(17):12738-12760.
Li Y., Bedi R.K, Wiedmer L., Sun X., Huang D., Caflisch A..  2021.  Atomistic and thermodynamic analysis of N6-methyladenosine (mA) recognition by the reader domain of YTHDC1. Journal of Chemical Theory and Computation. 17(2):1240-1249.
Moroz-Omori E.V, Huang D., Bedi R.K, Cheriyamkunnel S.J, Bochenkova E., Dolbois A., Rzeczkowski M.D, Li Y., Wiedmer L., Caflisch A..  2021.  METTL3 inhibitors for epitranscriptomic modulation of cellular processes. ChemMedChem. 16(19):3035-3043.
2020
Bedi R.K, Huang D., Wiedmer L., Li Y., Dolbois A., Wojdyla J.A, Sharpe M.E, Caflisch A., Śledź P..  2020.  Selectively disrupting m6A-dependent protein-RNA interactions with fragments. ACS Chemical Biology. 15(3):618-625.
Bedi R.K, Huang D., Eberle S.A, Wiedmer L., Śledź P., Caflisch A..  2020.  Small-molecule inhibitors of METTL3, the major human epitranscriptomic writer. ChemMedChem. 15(9):744-748.
Li Y., Bedi R.K, Moroz-Omori E.V, Caflisch A..  2020.  Structural and dynamic insights into redundant function of YTHDF proteins. Journal of Chemical Information and Modeling. 60(12):5932-5935.
2019
Li Y., Bedi R.K, Wiedmer L., Huang D., Śledź P., Caflisch A..  2019.  Flexible binding of m6A reader protein YTHDC1 to its preferred RNA motif. Journal of Chemical Theory and Computation. 15(12):7004-7014.
Wiedmer L., Eberle S.A, Bedi R.K, Śledź P., Caflisch A..  2019.  A reader-based assay for m6A writers and erasers. Analytical Chemistry. 91(4):3078-3084.