Structural and dynamic insights into redundant function of YTHDF proteins

TitleStructural and dynamic insights into redundant function of YTHDF proteins
Publication TypeJournal Article
Year of Publication2020
AuthorsLi Y., Bedi R.K, Moroz-Omori E.V, Caflisch A.
JournalJournal of Chemical Information and Modeling
Date Published2020 Oct 19
Type of ArticleResearch Article
ISSN1549-960X
Abstract

Three YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) recognize the N-methyladenosine (mA) modification of mRNA in cells. However, the redundancy of their cellular functions has been disputed. We investigate their interactions with mA-containing RNA using X-ray crystallography and molecular dynamics (MD). The new X-ray structures and MD simulations show that the three proteins share identical interactions with the mA-containing RNA and have similar intrinsic plasticity, thus evidencing the redundant roles of the three proteins in cellular functions.

DOI10.1021/acs.jcim.0c01029
pubindex

0260

Alternate JournalJ. Chem. Inf. Model.
PubMed ID33073985