Link to full page (citation export, more details):

Protein folding: Simple models for a complex process

Full Text PDF:

PDF icon caflisch04.pdf

A. Caflisch

Journal: Structure
Year: 2004
Volume: 12
Issue: 10
Pages: 1750-1752
DOI: 10.1016/j.str.2004.09.001
Type of Publication: Journal Article

Models, Chemical; Models, Molecular; Protein Conformation; Protein Folding; Proteins


Twenty-eight years after its original publication, the diffusion-collision model has successfully been applied to describe the folding kinetics of two proteins with the same native structure but different sequences (Islam et al., this issue of Structure). The calculations show the relative importance of the primary and tertiary structure on the sequence of events and folding. For both proteins, the model suggests parallel folding pathways, a finding which has wide implications for the interpretations of experiments.