Protein folding: Simple models for a complex process

TitleProtein folding: Simple models for a complex process
Publication TypeJournal Article
Year of Publication2004
AuthorsCaflisch A.
JournalStructure
Volume12
Issue10
Pagination1750-1752
Date Published2004 Oct
Type of ArticleCommentary
ISSN0969-2126
KeywordsModels, Chemical, Models, Molecular, Protein Conformation, Protein Folding, Proteins
Abstract

Twenty-eight years after its original publication, the diffusion-collision model has successfully been applied to describe the folding kinetics of two proteins with the same native structure but different sequences (Islam et al., this issue of Structure). The calculations show the relative importance of the primary and tertiary structure on the sequence of events and folding. For both proteins, the model suggests parallel folding pathways, a finding which has wide implications for the interpretations of experiments.

DOI10.1016/j.str.2004.09.001
pubindex

0060

Alternate JournalStructure
PubMed ID15458624
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