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Folding for binding or binding for folding?

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A. Caflisch

Journal: Trends Biotechnol.
Year: 2003
Volume: 21
Issue: 10
Pages: 423-425
DOI: 10.1016/S0167-7799(03)00208-7
Type of Publication: Journal Article

Models, Molecular; Models, Statistical; Proliferating Cell Nuclear Antigen; Protein Binding; Protein Folding; Proteins; Stochastic Processes; Structure-Activity Relationship


A number of proteins are partially unstructured under physiological conditions and assume a well-defined three-dimensional structure only upon binding to another protein or macromolecular complex. Numerous examples have been found, especially among proteins involved in regulatory functions in eukaryotic cells. Recent computer simulations by Verkhivker et al. yielded an atomic-detail picture of the folding of p27 and its concomitant binding to the phosphorylated cyclin A–cyclin dependent kinase 2.