Folding for binding or binding for folding?

TitleFolding for binding or binding for folding?
Publication TypeJournal Article
Year of Publication2003
AuthorsCaflisch A.
JournalTrends in Biotechnology
Volume21
Issue10
Pagination423-425
Date Published2003 Oct
Type of ArticleCommentary
ISSN0167-7799
KeywordsModels, Molecular, Models, Statistical, Proliferating Cell Nuclear Antigen, Protein Binding, Protein Folding, Proteins, Stochastic Processes, Structure-Activity Relationship
Abstract

A number of proteins are partially unstructured under physiological conditions and assume a well-defined three-dimensional structure only upon binding to another protein or macromolecular complex. Numerous examples have been found, especially among proteins involved in regulatory functions in eukaryotic cells. Recent computer simulations by Verkhivker et al. yielded an atomic-detail picture of the folding of p27 and its concomitant binding to the phosphorylated cyclin A–cyclin dependent kinase 2.

DOI10.1016/S0167-7799(03)00208-7
pubindex

0051

Alternate JournalTrends Biotechnol.
PubMed ID14512226
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