Kinetic control of amyloidogenesis calls for unconventional drugs to fight Alzheimer's disease
| Title | Kinetic control of amyloidogenesis calls for unconventional drugs to fight Alzheimer's disease |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Caflisch A. |
| Journal | ACS Chemical Neuroscience |
| Volume | 11 |
| Issue | 2 |
| Pagination | 103-104 |
| Date Published | 2020 Jan 15 |
| Type of Article | Research Article |
| Keywords | Alzheimer’s disease, amyloidogenesis, coarse-grained simulations, fibrillogenesis, molecular dynamics |
| Abstract | Computer simulations had predicted that amyloid fibrillogenesis is governed by free energy barriers and kinetic traps (kinetic control), rather than the free energy of the final aggregates. The simulations suggested that the diversity in fibril morphologies can originate from variations in the number of protofilaments which has been confirmed by recent cryo-electron microscopy studies of amyloid-β fibrils derived from brain tissue of Alzheimer's patients. The kinetic control of fibril formation and polymorphism imply that chemical substances with new mechanisms of action are needed to fight Alzheimer's disease. |
| DOI | 10.1021/acschemneuro.9b00676 |
| pubindex | 0251 |
| Alternate Journal | ACS Chem. Neurosci. |
| PubMed ID | 31904213 |
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