Data publication with the structural biology data grid supports live analysis

TitleData publication with the structural biology data grid supports live analysis
Publication TypeJournal Article
Year of Publication2016
AuthorsMeyer P.A, Socias S., Key J., Ransey E., Tjon E.C, Buschiazzo A., Lei M., Botka C., Withrow J., Neau D., Rajashankar K., Anderson K.S, Baxter R.H, Blacklow S.C, Boggon T.J, Bonvin A.MJJ, Borek D., Brett T.J, Caflisch A., Chang C.-I., Chazin W.J, Corbett K.D, Cosgrove M.S, Crosson S., Dhe-Paganon S., Di Cera E., Drennan C.L, Eck M.J, Eichman B.F, Fan Q.R, Ferré-D'Amaré A.R, Fromme J.C, Garcia K.C, Gaudet R., Gong P., Harrison S.C, Heldwein E.E, Jia Z., Keenan R.J, Kruse A.C, Kvansakul M., McLellan J.S, Modis Y., Nam Y., Otwinowski Z., Pai E.F, Pereira P.JB, Petosa C., Raman C.S, Rapoport T.A, Roll-Mecak A., Rosen M.K, Rudenko G., Schlessinger J., Schwartz T.U, Shamoo Y., Sondermann H., Tao Y.J, Tolia N.H, Tsodikov O.V, Westover K.D, Wu H., Foster I., Fraser J.S, Maia F.RNC, Gonen T., Kirchhausen T., Diederichs K., Crosas M., Sliz P.
JournalNature Communications
Volume7
Pagination10882
Date Published2016 Mar 07
Type of ArticleResearch Article
ISSN2041-1723
KeywordsCrystallography, X-Ray, Databases, Genetic, Internet, Macromolecular Substances, Publications, Software
Abstract

Access to experimental X-ray diffraction image data is fundamental for validation and reproduction of macromolecular models and indispensable for development of structural biology processing methods. Here, we established a diffraction data publication and dissemination system, Structural Biology Data Grid (SBDG; data.sbgrid.org), to preserve primary experimental data sets that support scientific publications. Data sets are accessible to researchers through a community driven data grid, which facilitates global data access. Our analysis of a pilot collection of crystallographic data sets demonstrates that the information archived by SBDG is sufficient to reprocess data to statistics that meet or exceed the quality of the original published structures. SBDG has extended its services to the entire community and is used to develop support for other types of biomedical data sets. It is anticipated that access to the experimental data sets will enhance the paradigm shift in the community towards a much more dynamic body of continuously improving data analysis.

DOI10.1038/ncomms10882
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Alternate JournalNat Commun
PubMed ID26947396
PubMed Central IDPMC4786681
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