Fast protein folding on downhill energy landscape
| Title | Fast protein folding on downhill energy landscape |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Cavalli A., Haberthür U., Paci E., Caflisch A. |
| Journal | Protein Science |
| Volume | 12 |
| Issue | 8 |
| Pagination | 1801-1803 |
| Date Published | 2003 Aug |
| Type of Article | Research Article |
| Keywords | Algorithms, Computer Simulation, Models, Chemical, Protein Folding, Protein Structure, Secondary, Proteins, Thermodynamics, Time Factors |
| Abstract | Proteins fold in a time range of microseconds to minutes despite the large amount of possible conformers. Molecular dynamics simulations of a three-stranded antiparallel β-sheet peptide (for a total of 12.6 μs and 72 folding events) show that at the melting temperature the unfolded state ensemble contains many more conformers than those sampled during a folding event. |
| DOI | 10.1110/ps.0366103 |
| pubindex | 0050 |
| Alternate Journal | Protein Sci. |
| PubMed ID | 12876329 |
| PubMed Central ID | PMC2323966 |
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