Flexible Binding of m6A Reader Protein YTHDC1 to Its Preferred RNA Motif

The movie shows dynamic interactions between m6A reader protein YTHDC1 and its preferred RNA motif GG(m6A)CU. m6A is captured by an aromatic cage of YTHDC1 (the residues shown in green sticks) and the 3′ terminus nucleotides are stabilized by cation−π–π interactions, while the 5′ terminus remains extremely flexible.

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