%0 Journal Article %K Models, Molecular %K Thermodynamics %K Drug Design %K Humans %K Protein Conformation %K Binding Sites %K Ligands %K Molecular Structure %K Static Electricity %K Thrombin %K Macromolecular Substances %K Software %K Computer-Aided Design %K Enzyme Inhibitors %K Methylguanidine %K Pyrrolidines %B Journal of Computer-Aided Molecular Design %D 1996 %G eng %N 5 %P 372-396 %T Computational combinatorial ligand design: application to human α-thrombin %V 10 %1 0009 %8 1996 Oct %9 Research Article